Very important research to reflect on regarding the primary mechanism for long Covid clots. This is especially important because this process may also be occurring across the population, even in those who have not got any symptoms.
Interestingly, I did a quick search for “microclots” OR “micro thrombi” on Google Scholar and could not find much research to suggest this was previously a close association with MECFS. Happy if someone could clarify that further.
If this process is primarily related to moderate/severe COVID-19 and long Covid, it could suggest the mechanism is mainly tied to the spike protein.
This cohort of patients below was between March 2020 and September 2020, therefore representative of Covid without any confounding factors of the vaccine.
Interestingly, long haulers who attended the COVID-19 recovery clinic in the Shaare Zedek Medical Center had significantly higher levels of NETosis induction than the long haulers who did not attend the clinic, and a significant difference in NETosis induction was maintained for patients in the COVID-19 recovery clinic with the most common symptoms. In summary, patients with symptoms severe enough to seek post-COVID medical care strikingly maintained a systemic plasma environment conducive to NET formation.
Krinsky, Nitzan, et al. "NETosis induction reflects COVID-19 severity and long COVID: insights from a 2-center patient cohort study in Israel." Journal of Thrombosis and Haemostasis (2023).
Is Netosis the cause of Long Covid Microclots?