25 Comments
Aug 4, 2023Liked by Dr Philip McMillan

This is a general view and advisory from me. Long covid has so many manifestations though a patient may be burdened only with two or three or four. It is important for all doctors and physicians and specialists around the world to be fully aware of these manifestations and their background. They must also recognise that much of this could be repeat vaccine mediated. So, if any patient, especially their regular ones, reports a condition not experienced by him before, the doctor must look into the vaccine angle closely and dispassionately, with an open mind. For example, if his 85 year old patient, who has been generally healthy otherwise and conducting himself normally, exhibits early Parkinson’s like symptoms, the vaccination history must be a top consideration. This might require additionally medicines that can clear the resident synthetic virus protein segments in the body, a course of anti histamines possibly. Hope I am making sense, even though I am not a medical practitioner.

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Aug 4, 2023·edited Aug 4, 2023Liked by Dr Philip McMillan

Looking forward to new insights into primary pathogenesis, Dr McMillan!

I found this project - The Remission Biome - to be deeply interesting with some important-looking hypotheses and experiences which to my untrained eye link to some of the work of Dr Brogna and colleagues as well as some of your interests. Essentially they are developing protocols for a patient-led initiative arising from their discovery that their long-term ME/CFS went into a short but complete remission when taking antibiotics for unrelated reasons. The project is currently piloting with 50 participants and expanding thereafter.

https://remissionbiome.org/our-story/

This comment on Dr Prusty's recent preprint on reactivated viruses gives a very good flavour of the quality of thinking. https://youtu.be/OZfv8xbadxM

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author

Important research but still doesn't explain why everyone is not affected.

There is another factor in play.

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Saw this thought you might like it.

KEN LASSESEN

https://www.facebook.com/groups/Health.Research.Group/permalink/1659613857881998/

Another report on another participant on the "Remission Biome Project" for ME/CFS. This project uses rotating antibiotics as part of the treatment protocol.

Subjective and Objective measurements are improving for this individual also.

MICROBIOME PRESCRIPTION BLOG

A site exploring the microbiome, what it affects and how to manipulate it.

https://blog.microbiomeprescription.com/2023/08/03/the-remission-biome-project-tamara-romanuk/

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Aug 4, 2023·edited Aug 4, 2023Liked by Dr Philip McMillan

"So, the cause is not an immune problem, but rather a persistent infection that results in or produces immune problems."

👇

Dr. Gustavo Aguirre-Chang

https://twitter.com/Aguirre1Gustavo/status/1559965029641994241

It has been shown that

SARS COV-2 INFECTS T LYMPHOCYTES

CAUSING THEIR EXHAUSTION AND APOPTOSIS

CONTRIBUTING TO IMMUNE DYSFUNCTION AND LYMPHOPENIA

THAT FAVORS VIRAL PERSISTENCE

Lymphopenia is associated with a higher Viral Load and Viral Persistence in COVID

SARS COV-2 INFECTS T LYMPHOCYTES CAUSING THEIR EXHAUSTION AND APOPTOSIS CONTRIBUTING TO IMMUNE DYSFUNCTION AND LYMPHOPENIA THAT FAVORS VIRAL PERSISTENCE

https://www.researchgate.net/publication/359330070_SARS_COV-2_INFECTS_T_LYMPHOCYTES_CAUSING_THEIR_EXHAUSTION_AND_APOPTOSIS_CONTRIBUTING_TO_IMMUNE_DYSFUNCTION_AND_LYMPHOPENIA_THAT_FAVORS_VIRAL_PERSISTENCE

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author

Certainly truth there.

Only difference in thought is that it is not active infection.

Still persistent impact on lymphocytes.

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I recall Dr. Shankara Chetty conveying in an interview with you (Dr. McMillan) that LC may not be due to residual viral loads, but a kind of dysfunctional immune activity. His protocol included anti histamines and immune modulators including steroids. Do all these views square up to an unified picture ?

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Aug 4, 2023·edited Aug 4, 2023Liked by Dr Philip McMillan

SEE COMMENTS

⛔️ Jean Michel Wendling "A SARS COV2 reservoir in the intestine is suspected"

…..

⛔️ Guy Van den Eede "see our paper for more evidence."

The Long Covid blood samples were also awash with a category of “exhausted” T cells that can be recognized by certain markers they express. Such cells surge in the ongoing presence of pathogens—suggesting “the bodies of people with Long Covid are actively fighting something,” Putrino says.

Professor Erwin Loh

https://www.linkedin.com/posts/erwinloh_longcovid-blood-fatigue-activity-6965645627112263680-EBrg

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One angle you have not “researched” is the hard data/research of Dr Ana Mihalcea--why is that?

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author

What is she saying?

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A good place to start is the Substack of Dr Ana Mihalcea and also Substack of Karen Kingston.

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I would consider LC or LV (Long vax) as 75% pathogenic condition and 25% as mitochondrial damage. The second part ha s to be a slow recovery aided by food choice and supplements. There are at least two medical professionals in this sub stack who are following this after they contracted LC. Body can slowly eliminate the first part also on its own whether the pathogenic condition is immune, inflammation or allergy derived or even lingering infection. This can be an even slower process, dragging down the mitochondrial recovery and forcing the LC to last long. This is what they have done taking upto two years for total recovery. I feel the pathogenic part can be safely, securely and quickly handled with a compliment of established medicines, including anti histamines. At least major part of it. This basically entails the flushing out of the residual viral load totally, while working to mitigate the immune, inflammation, allergy or infection. A whole compliment of established medicines clinically thoughtfully chosen. Thus, the body can be freed in time, to focus fully on the mitochondrial recovery and hasten it up. The protocol for this recovery can be rendered less elaborate as a result. In the next meet with experts, especially on LC, I request Dr. McMillan to discuss this template for treating LC. This can apply to patients who could be of LV origin also. The LV/LC picture in the USA appears depressing. The official guidelines seem blinkered. No one is seen to be taking the bull (the issue) by the horn.

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The WP reports today that NIH will take up 5 investigations on long covid (atlast 😳), involving patient level trials. It still fails to recognise that the infection may have started it all as long covid, but it could be all about long vax. The first trial will involve residual viral load elimination using courses of Paxlovid. This is classic frog in the well story. Instead of looking at the rich experience from around the world of countries preventing/mitigating/eliminating LC to the point of non existence using classical, time tested medications, NIH believes Paxlovid is the only recourse. So be it. Let us hope something tangible and tenable comes out of these studies, for the sake of millions of unsuspecting Americans long battered by this condition.

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Aug 5, 2023·edited Aug 5, 2023

Dr. Gustavo Aguirre-Chang

https://twitter.com/Aguirre1Gustavo/status/1686572608509075456

VIRAL PERSISTENCE UP TO 2 YEARS POST-COVID

In all participants with Long COVID

SARS-CoV2 was identified in the lamina propria of Rectosigmoid

They had up to 676 days of persistence Post-Acute COVID

Findings support our Protocols with Drugs against Viral Load.

Multimodal Molecular Imaging Reveals Tissue-Based T Cell Activation and Viral RNA Persistence for Up to 2 Years Following COVID-19

https://www.medrxiv.org/content/10.1101/2023.07.27.23293177v1

“We identified that SARS-CoV-2 persistence is one potential driver of this ongoing activated immune state, and we show that SARS-CoV-2 RNA may persist in gut tissue for nearly 2 years after the initial infection.”

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I had written in Oct 22 in another context in a file shared with many including Dr. McMillan that long covid is due to the presence of residual viral loads, migrated to several places in the body, not strong enough to cause a covid reinfection, but sufficient to cause problems where it had taken shelter. I also mentioned this is due to failure to undergo early medications that would have curtailed viral load build up in the initial phase of the disease. I hope researchers have found this link. A classical multi drug URT prescription was all that was required. I had mentioned that vaccines were a red herring in the long covid story, but now that could be the top most reason, remnant viral protein segments from the vaccines. Structurally this must be different from remnants of natural virus. I do hope researchers are gathering data on this question also in long covid patients. It is impossible for one Dr. McMillan to be looking into the several angles of research on long covid. It would be of great interest to know what exactly the medicinal protocol that this group ( is the curve flat yet) followed to curtail viral load and the passage of the disease as a result. For example, did their protocol prevented entry of patients into the deadly autoimmune phase, did it prevent the incidence of long covid ? These are all very important observations. Incidentally, if this group (?) is from the USA, their name question makes sense. The answer is NOT yet. If they are from some other parts of the world, they would know that the curve has long merged with the X axis.

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Don’t know if this would be interesting for you.

KEVIN MC KERNAN SUBSTACK

Can qPCR differentiate Vax Spike from C19 Spike

https://anandamide.substack.com/p/can-qpcr-differentiate-vax-spike

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This sub stack within sub stack is a bit distracting. Often where simple known information will do. Now to my earlier two points. If the vax spike could be differentiated from C19 spike in lab tests, is there someway of studying medicines that could eliminate the resident spikes and thereby start recovery from long vax/long covid ? Now that is more important. Second, I am still looking for specific details of protocols (medicines) used for viral load prevention. Grape seed oil looks unconvincing. It is not magical. The same fatty acid composition can be obtained by calculated blending more commonly used vegetable oils. If it is any minor constituent of grape seed oil, like any tocopherols etc, they could as well be obtained by grapes directly. Grape seed oil can certainly be an adjuvant in any treatment, main items will have to be somethings else.

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GSE grapefruit seed extract not grape seed oil. Go see what people post come back and tell us what you find.

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I stand corrected. I am aware of the difference. Even so, you must explain what is special about grapefruit seed oil that provides viral load control, if it was the only item used in the treatment. Theoretically, even its fatty acid profile can be replicated by blending known common o vegetable oils available everywhere, if the fatty acid profile is the active reason. Being a citrus fruit, even its seed could be vit C rich, besides the bitter principles in it. Is it this principles that could be present in oil that is the medicinal role in viral load control.? The interest is about the details of the therapy employed. That is my original request. We must look at these conversations as means of arriving at possible treatment options for long covid through exchange of views and experiences.

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Aug 5, 2023·edited Aug 5, 2023

I agree with what I have read etc LC is viral persistence it harbours in just about all parts of the body, it can be undetected, it can hide in biofilms, in macrophages etc, sneaky virus.

..

Carlo Brogna wrote a book years ago with pictures of it in poop replicating, telling you what antibiotics he used etc.

..

Toxic poop and fungus bacteria etc from the gut translocates into the blood stream, goes everywhere. The immune system is on fire.

..

SC2 has a dual mechanism it infects human cells but first infects bacterial cells in the microbiome. Consequences = release of toxins that go into the blood stream, disrupts the CNS and gut-brain axis…. Carlo Brogna.

Dr Chang says

“Unlike Dr P. and other Teams

Since March 2020 we are sure that there is Viral Persistence

And it's not just SARS CoV2

EBV, HHV often co-exist

and other microorganisms

part may come from microbiota

Going against the Viral/Microbial Load is our main objective”

…..

THE GUT CLUB ⬇️

If you look in comments click link by Keith Bell it goes to 2020

https://www.facebook.com/thegutclub23/photos/a.1277925552233310/8348941598464968/

I would use GSE ( grapefruit seed extract ) or Oregano oil. I did buy Dr Dietrich’s recommended tinctures years ago at the beginning, which I still have, but I haven’t taken anything so far. I’m growing tobacco for nicotine someone sent me seeds to a good plant.

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Gustavo Aguirre Chang

https://twitter.com/Aguirre1Gustavo/status/1609607627981619200

SARS COV2 INFECTION

TRANSMITTED BY A LUNG TRANSPLANT DONOR

Nasopharyngeal PCR tests were Negative before transplantation

Donor transmission was confirmed by PCR+ of lung Bronchoalveolar lavage (BAL) samples

This is now mandated

so this risk will be reduced

https://www.jhltonline.org/article/S1053-2498(22)01380-8/pdf

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Dr. Gustavo Aguirre-Chang

https://twitter.com/Aguirre1Gustavo/status/1678893715169894401

Interview that the Long COVID Apheresis Community carried out on me

I mention:

Treatment against Viral Load

Therapeutic Test for Viral Persistence

The free Test with which in a few minutes you can perform the Clinical Diagnosis of Microclots/Bioclots

And +

Long Covid Apheresis Community - Expert Interviews: Dr. Gustavo Aguirre-Chang

https://youtu.be/oyDH_KvBymI

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This is an very useful interview about effective treatments against persistent infections that, according to our research, are the most frequent cause of post covid or LONG COVID and also chronic fatigue syndrome of the diseases considered autoimmunity and several other diseases.

-

Three objectives are shown, which are valid for both acute covid and chronic covid, which is LONG COVID. Because LONG COVID is a continuation of the same covid disease. But in POST COVID there is a spread of the infection no longer only lungs are affected, rather the infection spreads to the intestines and other extrapulmonary organs. It effects the walls of the blood vessels, especially the smallest ones.

-

We are also using this therapeutic plan that we created for covid for chronic fatigue syndrome, arthritis, lupus syndrome, and other diseases considered autoimmune which we associate with an external or foreign causal factor to the organism, mainly microorganisms that can come from outside BUT it can often also be microorganisms from our own flora.

-

That is to say that they are already inhabiting the organism, perhaps the case of CANDIDA or STAPHYLOCOCCUS AUREUS that many people contribute and when a viral infection or a state of weakness of the person occurs an overgrowth of these microorganisms causes diseases.

-

QUESTION

......You have told us about 2020 and 2021. What have you learned from all of this in the last 2 years?

ANSWER

During the first two years, the most difficult cases were solved. And the cases have remained for the most part are already cases that are more persistent and more difficult to treat. Well, let me correct, the first two years the Easter cases were solved, and the ones that have remained more complex and persistent. And the persistence of viruses and other microorganisms is associated with the persistence of what we call BIOFILMS that are structures that microorganisms create to provide PROTECTION of refuge and become more resistant against the immunity and against drugs.

For decades the presence of BIOFILMS have been described in the oral cavity and the intestines which are places where a large number of microorganisms live.

But at the level of blood vessels, microorganisms also seek to create BIOFILMS. The BIOFILMS of the blood vessels are not the same as those of the mouth and the intestines.

At the level of the blood vessels, the microorganisms seem to persist and for this they can look for an environment which they can use to PROTECT themselves.

And what we have observed is that platelets and other elements use FIBRIN to create a favourable micro environment in which to PERSIST.

In the graph we show how FIBRIN deposits form small micro clots that because they fulfil the function of BIOFILMS, which we have called BIOFILMS or BIOCLOTS.

And these BIOFILMS and BIOCLOTS are related to a greater presence of DRUG RESISTENCE.

And also to the so called REBOUNDS or REACTIVATIONS of persistent infections.

So in the last two years we faced this PERSISTENT infections with the presence of BIOFILMS and RESERVOIRS and with some degree of Drug resistence.

-etc

ANSWER

Yes, in fact it happens that SARS COV 2 virus continues to mutate within the organism of the patients and also increasingly creates more BIOFILMS or refuges to PERSIST longer.

Therefore, in patients with a greater number and severity of MICROCLOTS symptoms, it will be unlikely that medication alone will achieve a large reduction or eradication of the VIRAL LOAD.

Therefore effective procedures such as Apheresis and others are required.

-

ANSWER

Patients should not wait so long. VIRAL PERSISTENCE is very evident. Although it’s not the only cause, we estimate that around 75% of patients with post Covid or LONG COVID have VIRAL PERSISTENCE with clinical evaluation a diagnosis of a syndrome of

hyperfusion and hypercoagulability and microclots can be made. Which in a simplified name we call HHM syndrome.

The most frequent cause is a persistent infection that effects the walls of the blood vessels.

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Gut tissues can retain SARS-CoV-2 particles after COVID-19 infection for more than one year after the resolution of COVID-19

👇

Gustavo Aguirre Chang

https://twitter.com/Aguirre1Gustavo/status/1608786500988305411

UNDIAGNOSED VIRAL PERSISTENCE

IN 32.5% OF PATIENTS UNDERGOING BARIATRIC SURGERY

All had Negative PCR before Surgery

They were unaware they had a Persistent Infection due to SARS-CoV-2

One part had more than 1 year since infection

Are undiagnosed Long Covid

Lingering SARS-CoV-2 in Gastric and Gallbladder Tissues of Patients with Previous COVID-19 Infection Undergoing Bariatric Surgery

https://link.springer.com/article/10.1007/s11695-022-06338-9

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deletedAug 4, 2023Liked by Dr Philip McMillan
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author

Long Covid needs to be able to explain MECFS and fibromyalgia.

Similar spectrum of disease.

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